ANALYTICAL METHODS BASED ON MASS SPECTROMETRY USED IN GENOMIC, PROTEOMIC AND METABOLOMIC STUDIES

Mădălina A. Davidescu, C-tin Pascal, A.C. Grădinaru, D. Simeanu, V. Maciuc, Şt. Creangă

Abstract
    This paper reviews the most important aspects of the literature on genomics, proteomics, and metabolomics studies based on analytical methods such as mass spectrometry (MS). Currently, most analyzes in the field of "omic" subjects are performed with mass spectrometers due to reproducible quantitative accuracy, and their ability to evaluate complex biofluids. This technology are faster, more sensitive, more reliable, and more automated than others. A huge demand for a software that can process, analyse, and visualize large data sets has been generated by the ability to characterize more metabolites and allowed by recent improvements in mass spectrometry instrumentation. The application of mass spectrometry to genome annotation presents a number of challenges to standard workflows in genomics.